Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c

Rosas-Cruz G.P.; Silva-Correa C.R.; Calderón-Peña A.A.; Villarreal-La Torre V.E.; Aspajo-Villalaz C.L.; Cruzado-Razco J.L.; Rosario-Chávarri J.D.; Rodríguez-Soto J.C.; Pretel-Sevillano O.E.; Sagástegui-Guarniz W.A.; González-Siccha A.D. · Pharmacognosy Journal (2020) · DOI: 10.5530/pj.2020.12.175

Resumen

Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato"were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation.

Instituciones: Universidad Nacional de Trujillo