Wallerian corticospinal tract degeneration due to brain tumor radiotherapy: Case report and review of the literature

Robles Díaz J.F. · Neurologia Argentina (2025) · DOI: 10.1016/j.neuarg.2025.07.003

Resumen

Wallerian degeneration (WD) refers to the pathological process of secondary degeneration of axons and myelin sheaths that occurs distal to the site of acute injury in the neuronal soma or proximal axon. A rare case is presented of a male patient with an intracerebral tumor who developed WD after receiving external radiotherapy. Clinically, he presented Weber syndrome. Magnetic resonance imaging of the brain in FLAIR and T2 sequences showed hyperintense corticospinal tract. Differential diagnoses and possible treatments are presented.

Instituciones: Universidad Peruana Los Andes