Triglyceride-Glucose Index as a predictor of severity in acute pancreatitis: Systematic Review and Meta-Analysis

Vásquez-Tirado G.A.; Aguirre-Varas O.Y.; Meregildo-Rodríguez E.D.; Quispe-Castañeda C.V.; Guzmán-Aguilar W.M.; Liñán-Díaz L.J.; Rodríguez-Chávez L.Á. · Medicina Intensiva (2026) · DOI: 10.1016/j.medin.2025.502210

Resumen

Objective The triglyceride-glucose (TyG) index has been proposed as a novel predictive variable of severe acute pancreatitis (SAP) Design Systematic review and meta-analysis. Setting A comprehensive search was conducted across five databases of studies published up to March 17, 2024, using the PECO strategy. Seven studies were identified and included in our meta-analysis. Participants The participants of the included primary studies (non-severe acute pancreatitis). Interventions High triglyceride-glucose (TyG) index Main variables of interest Severe acute pancreatitis, Results Our analysis evaluated the risk of progression to severity in patients with elevated TyG index in acute pancreatitis through four non-randomized studies. The TyG index was found to be a predictor of severity in acute pancreatitis, with an overall severity risk (OR: 2.38; 95% CI: 1.50–4.08; I²: 80%). Additionally, the analysis of the standardized mean difference (SMD) across all seven studies between patients with SAP and non-SAP yielded an overall mean (OR: 0.90; 95% CI: 0.70–1.11; I²: 28%). Conclusion In patients with acute pancreatitis, a TyG index is a predictor of severity.

Instituciones: Universidad Nacional de Trujillo; Universidad Privada Antenor Orrego; Universidad Señor de Sipán