The role of miRNA-128 in the development and progression of gastrointestinal and urogenital cancer

Al-Awsi G.R.L.; Jasim S.A.; Fakri Mustafa Y.; Alhachami F.R.; Ziyadullaev S.; Kandeel M.; Abulkassim R.; Sivaraman R.; Hameed N.M.; Parra R.M.R.; Karampoor S.; Mirzaei R. · Future Oncology (2023) · DOI: 10.2217/fon-2022-0574

Resumen

Increasing data have shown the significance of various miRNAs in malignancy. In this regard, parallel to its biological role in normal tissues, miRNA-128 (miR-128) has been found to play an essential immunomodulatory function in the process of cancer initiation and development. The occurrence of the aberrant expression of miR-128 in tumors and the unique properties of miRNAs raise the prospect of their use as biomarkers and the next generation of molecular anticancer therapies. The function of miR-128 in malignancies such as breast, prostate, colorectal, gastric, pancreatic, esophageal, cervical, ovarian and bladder cancers and hepatocellular carcinoma is discussed in this review. Finally, the effect of exosomal miR-128 on cancer resistance to therapeutics and cancer immunotherapy in certain malignancies is highlighted.

Instituciones: Universidad Continental