The role and mechanism of action of microRNA-122 in cancer: Focusing on the liver

Al-Gazally M.E.; Khan R.; Imran M.; Ramírez-Coronel A.A.; Alshahrani S.H.; Altalbawy F.M.A.; Turki Jalil A.; Romero-Parra R.M.; Zabibah R.S.; Shahid Iqbal M.; Karampoor S.; Mirzaei R. · International Immunopharmacology (2023) · DOI: 10.1016/j.intimp.2023.110713

Resumen

microRNA-122 (miR-122) is a highly conserved microRNA that is predominantly expressed in the liver and plays a critical role in the regulation of liver metabolism. Recent studies have shown that miR-122 is involved in the pathogenesis of various types of cancer, particularly liver cancer. In this sense, The current findings highlighted the potential role of miR-122 in regulating many vital processes in cancer pathophysiology, including apoptosis, signaling pathway, cell metabolism, immune system response, migration, and invasion. These results imply that miR-122, which has been extensively studied for its biological functions and potential therapeutic applications, acts as a tumor suppressor or oncogene in cancer development. We first provide an overview and summary of the physiological function and mode of action of miR-122 in liver cancer. We will examine the various signaling pathways and molecular mechanisms through which miR-122 exerts its effects on cancer cells, including the regulation of oncogenic and tumor suppressor genes, the modulation of cell proliferation and apoptosis, and the regulation of metastasis. Most importantly, we will also discuss the potential diagnostic and therapeutic applications of miR-122 in cancer, including the development of miRNA-based biomarkers for cancer diagnosis and prognosis, and the potential use of miR-122 as a therapeutic target for cancer treatment.

Instituciones: Universidad Continental