The hispanic landscape of triple negative breast cancer

Zevallos A.; Bravo L.; Bretel D.; Paez K.; Infante U.; Cárdenas N.; Alvarado H.; Posada A.M.; Pinto J.A. · Critical Reviews in Oncology/Hematology (2020) · DOI: 10.1016/j.critrevonc.2020.103094

Resumen

Triple-negative breast cancer (TNBC) is a heterogeneous and complex disease characterized by the absence of immunohistochemical expression of estrogen receptor, progesterone receptor and HER2. These breast tumors present an aggressive biology and offer few opportunities to be treated with targeted therapy resulting in bad disease outcomes. The epidemiology of TNBC is intriguing where the understanding of its biology has progressed quickly. One of the peculiarities of this type of cancer is a high prevalence in Afrodescendants and Hispanic patients compared to Caucasian women. In this review we describe some features of TNBC, focusing in the Hispanic population, such as epidemiological, clinicopathological features and molecular features and the correlation between TNBC prevalence and the human development index.

Instituciones: Universidad Nacional San Luis Gonzaga; Universidad Privada San Juan Bautista