The Challenges of Antitubercular Drug Discovery

Prates J.L.B.; dos Santos Fernandes G.F.; Rodríguez-Silva C.N.; dos Santos J.L. · Integrated Science (2023) · DOI: 10.1007/978-3-031-15955-8_23

Resumen

Although extensive efforts have been undertaken to eradicate tuberculosis (TB), it remains one of the deadliest infections. The rising number of drug-resistant strainsStraindrug-resistant contributing to high mortalityMortality rates has become a global concern, highlighting the need for suitable treatments to eliminate such strains. However, the limitations of current therapies are long treatment duration, adverse side effectsSide effect, interactions with other drugs, toxicity, and poor efficacyEfficacy against latent strains. Thus, the search for safe and effective anti-TB drugsDruganti-TB is urgent. This chapter addresses the advances and challengesChallenge in drug discoveryDiscoverydrug for treating TB by focusing on the recently approved drugsDrugApproved and the most promising candidatesCandidate that can contribute to current therapies. Antitubercular drug discovery: challenges © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

Instituciones: Universidad Nacional de Trujillo