Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model

Herrera-Calderon O.; Bulege-Gutiérrez W.; Javier-Silva L.A.; Iparraguirre-Meza M.; Sanchez-Araujo V.G.; Melgar-Merino E.J.; Tinco-Jayo J.A.; Almeida-Galindo J.S.; Pari-Olarte J.B. · Pharmacognosy Journal (2023) · DOI: 10.5530/pj.2023.15.97

Resumen

Background: Tanacetum parthenium (L.) Sch Bip known as "santa maría"(Asteraceae family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. Objective: The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of T. parthenium Material and Methods: Leaves and flowers of T. parthenium were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method. Results: Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC50 showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. Conclusions: The ethanolic extract of flowers of T. parthenium showed a high antioxidant activity and antinociceptive effect in mice.

Instituciones: Universidad Nacional Mayor de San Marcos; Universidad Nacional San Luis Gonzaga; Universidad Nacional de Huancavelica; Universidad Continental; Universidad Peruana Los Andes; Universidad Nacional de San Cristóbal de Huamanga; Universidad Privada del Norte