T LYMPHOCYTE LEVELS PRE AND POST VITAMIN C INFUSION IN PEOPLE NOT INFECTED WITH SARS-COV-2

Romero S.E.; Paredes J.A.; Espillco X.; Moya J.; Rodriguez R.; Gomez-Gonzales W. · Georgian Medical News (2025)

Resumen

Introduction: Vitamin C is a micronutrient with immunomodulatory potential, involved in lymphocyte differentiation and activation, as well as in the regulation of oxidative stress and inflammation. During the COVID-19 pandemic, interest in its use as a therapeutic adjuvant has emerged. However, there is little evidence regarding its effects on healthy individuals not infected with SARS-CoV-2. Methods: A quasi-experimental study was conducted in healthy adults without respiratory symptoms who received intravenous vitamin C at a dose of 7.5 g for three consecutive days. Leukocyte population levels, including CD4+ and CD8+ T lymphocytes, were assessed before and after the intervention using flow cytometry. Statistical analysis included significance tests for pre- and post-intervention differences. Results: Statistically significant increases in CD4+, CD8+ T lymphocyte, and eosinophil levels were observed after vitamin C administration. No significant differences were found based on sociodemographic variables. The results remained within accepted biological variability ranges, supporting their consistency. Conclusion: High-dose intravenous vitamin C may have an immunostimulatory effect in healthy individuals, particularly on CD4+ and CD8+ T lymphocytes. Controlled clinical trials with greater methodological rigor are needed to confirm these findings and explore their applicability in immunocompromised populations.

Instituciones: Universidad Nacional Mayor de San Marcos; Universidad Privada San Juan Bautista