SYSTEMIC SCLEROSIS SINE SCLERODERMA IN A WOMAN WITH CENTROMERE ANTINUCLEAR ANTIBODIES, PULMONARY AND DIGESTIVE INVOLVEMENT: CASE REPORT

Liñán Ponce F.; Leiva Goicochea J.; Chávez Corrales J. · Revista de la Facultad de Medicina Humana (2023) · DOI: 10.25176/rfmh.v23i3.5670

Resumen

Introduction: Sine entities are rare in rheumatology. In progressive systemic sclerosis there is a variant of the limited cutaneous form called systemic sclerosis sine scleroderma, whose central feature is the lack of skin involvement, but visceral involvement is present. Positive anti-topoisomerase or anti-centromere antibodies confirm the diagnosis. We present the case of a 63-year-old woman with interstitial lung disease, intestinal transit involvement and Raynaud's phenomenon, with high titers of ANA with a centromeric pattern and positivity for anti-topoisomerase antibodies. When faced with a patient with Raynaud's phenomenon, visceral involvement and elevated ANA, specific antibodies should be requested for the diagnosis of systemic sclerosis in its sine variety.