SYSTEMIC IMMUNE-INFLAMMATION INDEX AS A DIAGNOSTIC TOOL FOR SURGICAL SITE INFECTION IN PATIENTS UNDERGOING HERNIOPLASTY

Solorzano Llashac A.M.; Seas Nolazco H.W.; Roque-Quezada J.C.; Virú Flores H.M.; Soldevilla Collazos P.; Alburqueque-Melgarejo J. · Revista de la Facultad de Medicina Humana (2025) · DOI: 10.25176/rfmh.v25i3.7390

Resumen

Introduction: Preoperative systemic inflammation may predict surgical site infection (SSI) after primary inguinal hernioplasty. Objective: To evaluate the relationship between preoperative systemic immune-inflammation index (SII) and SSI. Methods: An analytical observational case-control study of patients undergoing primary inguinal hernioplasty was conducted at the Hospital Nacional Hipólito Unanue (HNHU) between 2019 and 2023. Cases were defined as those with SSI within 30 days, and controls as those without SSI. The sample, obtained through simple random sampling, included 429 patients (86 with SSI; 343 without SSI). The exposure was SII, calculated as (platelets × neutrophils)/lymphocytes. Receiver operating characteristic (ROC) curve analysis and logistic regression were applied to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Results: SII showed an area under the curve (AUC)=0.830; 95% CI: 0.765-0.895; p<0.001. The optimal cutoff point was 536.82, with 72/86 positive cases and 133/343 positive controls. At this threshold, sensitivity was 83.72%, specificity 61.22%, positive likelihood ratio 2.159, and negative likelihood ratio 0.265. In logistic regression, SII≥536.82 was associated with SSI (adjusted OR=6.180; 95% CI: 3.207-11.911; p<0.001), and male sex showed lower odds (adjusted OR=0.150; 95% CI: 0.082-0.275; p<0.001). Conclusion: Preoperative SII was a useful marker for predicting SSI and may therefore facilitate risk stratification. © It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/ non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited.

Instituciones: Universidad Científica del Sur; Universidad Ricardo Palma