Systematic review of preclinical studies on the effect of vitamins on bone regeneration

Becerra-Bravo M.A.; Becerra-Bravo K.Y.; Garcia-Dextre J.A.; Lam-Figueroa N.M.; Ruiz-Ramirez E. · Revista Cubana de Investigaciones Biomedicas (2025)

Resumen

Introduction: Vitamins are organic substances with biological properties on multiple tissues of the organism, including bone tissue; therefore, they may participate in the process of bone regeneration. Objective: To evaluate the effect of vitamins on the bone regeneration process in preclinical models of bone defects. Methods: The following systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The research question was constructed according to the PICO (Population, Intervention, Comparator, Outcome) model, and literature searches were performed in PubMed/Medline, Embase, Web of Science (WOS), Scopus and LILACS databases. Gray literature was also consulted in PROQUEST and Google Scholar. Bone regeneration” was probed as the main outcome. Results: Twenty-three articles were included for qualitative analysis; subsequently, quality was assessed using the Animal Reseach: Reporting of In Vivo Experiments (ARRIVE) tool and risk of bias was assessed using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE risk of bias tool). The main findings showed the action of vitamins on bone regeneration in induced bone defects in animals; however, data on the parameters analyzed similarly across studies were not retrieved. Conclusions: Current evidence suggests that vitamin administration promotes bone regeneration; however, further preclinical studies are required to confirm the effect of vitamins on bone defects.

Instituciones: Universidad Nacional Mayor de San Marcos