Synthesis of thioureas with structural isoniazid and niazid: test against Gram + and Gram – bacteria; [Síntese de tioureias com isoniazida e niazida estru-turais: teste contra bacté-rias Gram + e Gram –]

Angulo-Cornejo J.R.; Tovar-Taboada C.F. · Revista Colombiana de Quimica (2023) · DOI: 10.15446/rev.colomb.quim.v52n1.108362

Resumen

The compounds N-(2-nicotinoylhydra-zine-1-carbonothioyl)benzamide (H3 L1) and its isomer N-(2-isonicotinoylhydra-zine-1-carbonothioyl)benzamide (H3 L2) type N, S, O donors, by reaction of ben-zoyl isothiocyanate with nicotinic hydra-zide and isoniazid respectively were syn-thesized. The H3 L1 and H3 L2 compounds were characterized by1H-NMR,13C-NMR, FT-IR and elemental analysis. Computational analysis using the Fukui functions were performed to determine the reasons why the 1,2,4-triazoles were not formed. Preliminary tests of the synthesized compounds were carried out against Staphylo-coccus aureus (Gram+) and Escherichia coli (Gram-), having demonstrated significant activity against such bacteria.

Instituciones: Universidad Nacional Mayor de San Marcos