Synthesis of acylthioureas with ethyl piperazine-1-carboxylate in their structure: Fungicidal activity test against Aspergillus flavus; [Síntese de aciltioureas com piperazina-1-carboxilato de etila em sua estrutura: teste de atividade fungicida contra Aspergillus flavus]

Alcívar Rodríguez D.M.; Lino-Pacheco M.N.; Angulo-Cornejo J.R.; Navarrete Álava J.M. · Revista Colombiana de Quimica (2025) · DOI: 10.15446/rev.colomb.quim.v54n1.114831

Resumen

In this research, three acylthioureas containing ethyl piperazine-1-car-boxylate in their structure were synthesized: ethyl 4-(benzoylcarbamothiol) piperazine-1-carboxylate (L1), ethyl 4-((4-methylbenzoyl)carbamo-thi ol) piperazine-1-carboxylate (L2), and ethyl 4-((3-nitrobenzoyl)carbamothiol)pipe-razine-1-carboxylate (L3). The physical properties (melting point and solubility) of each ligand were characterized, and additional properties were identified using instrumental techniques such as elemental analysis, infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1H-NMR and13C-NMR), and X-ray photoelectron spectroscopy (XPS N1s). Subsequently, the antfungicidal activity of the three ligands against Aspergillus flavus was tested using the Kirby-Bauer method at three application percentages (0.5, 1.0, and 1.5%). The results demonstrated that the ligands inhibit fungal growth, highlighting the role of aromatic ring modification in biological activity and paving the way for the development of new antifungal agents.

Instituciones: Universidad Nacional Mayor de San Marcos