Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

Abascal E.; Herranz M.; Acosta F.; Agapito J.; Cabibbe A.M.; Monteserin J.; Ruiz Serrano M.J.; Gijón P.; Fernández-González F.; Lozano N.; Chiner-Oms Á.; Cáceres T.; Pintado P.G.; Acín E.; Valencia E.; Muñoz P.; Comas I.; Cirillo D.M.; Ritacco V.; Gotuzzo E.; García de Viedma D. · Scientific Reports (2020) · DOI: 10.1038/s41598-020-59373-w

Resumen

It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.

Instituciones: Universidad Peruana Cayetano Heredia