SAFETY AND PROTECTIVE EFFECTS OF CENCHRUS ECHINATUS ON INDUCED BREAST CANCER IN RATTUS RATTUS

Cisneros Hilario C.B.; Arroyo Acevedo J.L.; Bedoya Castillo M.P.; Lázaro Huamán B.A.; Mendoza Chávez K.E.; Cisneros Hilario E.J. · Revista de la Facultad de Medicina Humana (2022) · DOI: 10.25176/rfmh.v22i3.4915

Resumen

Introduction: Breast cancer is a disease that is increasing its incidence yearly; it is thus in search of complementary alternatives for treatment, some medicinal plants containing large amounts of polyphenols have been studied, which have anti-cancer effects as is the case of Cenchrus echinatus L. Objective: determine the safety and protective effect of the extract ethanolic of Cenchrus echinatus L. (cadillo) on 7,12- Dimethylbenzo[a]anthracene DMBA-induced breast cancer in Rattus rattus. Methods: Preclinical, experimental study in male Balb/C53 mice and Holtzman rats of both sexes. Acute toxicity (DL50) and toxicity at 45 days were calculated by methods of the probits and OECD respectively; to evaluate the protective effect the method of Barros 2004 was used, also the proliferation of tumor cells was recorded microscopically, using descriptive and inferential statistical analysis, considering p<0.05. Results: The safety studies demonstrate that the extract does not induce significant changes at the hematological, biochemical, and anatomopathological levels. A 76.92 % of the protective effect of the extract against DMBA-induced breast cancer in rats was achieved. Conclusions: It has been shown that the extract of Cenchrus echinatus L. presents a protective effect on 7,12-Dimethylbenzo[a]anthracene-induced breast cancer in Rattus rattus, and is not toxic to mice and rats.

Instituciones: Universidad Nacional Mayor de San Marcos; Universidad Ricardo Palma; Universidad César Vallejo