Risk of preeclampsia and Vitamin C and E supplementation: a systematic review and meta-analysis

Rebaza M.T.P.; Vera-Ponce V.J.; Torres-Malca J.R.; Talavera J.E.; Zuzunaga-Montoya F.E.; Cruz-Vargas J.A.D.L. · Revista Cubana de Medicina Militar (2022)

Resumen

Introduction: It has been suggested that preeclampsia can be prevented by vitamin E and C intake, given the pathophysiological mechanism of this disease. Objective: To determine the joint efficacy of vitamin C and E in the prevention of preeclampsia. Methods: Systematic review of randomized clinical trials. A search of pubmed/medline, SCOPUS, Web of Science, Cochrane Library, EMBASE, and Clinical Trials databases was performed. The risk of bias of the randomized clinical trials was assessed using the Cochrane tool version 2. A random-effects meta-analysis was performed and relative risks were calculated, with corresponding 95 % confidence intervals. Results: Seven studies were included (n= 1 475). No statistically significant association of treatment with vitamin C and E supplementation was found with respect to preeclampsia (relative risks: 1.03; 95 % CI 0.78-1.26). Conclusions: Dual vitamin C and E supplementation does not prevent preeclampsia in pregnant women at risk for the disease.

Instituciones: Universidad Ricardo Palma; Universidad Tecnológica del Perú