Rapidly progressive interstitial lung disease-associated hypomyopathic dermatomyositis complicated with pneumomediastinum: A case-based review

Cerna-López J.A.; Tejada-Llacsa P.J.; Valle-Farfán F.A.D.J.; Alarcón G.S.; Ugarte-Gil M.F.; Pimentel-Quiroz V.R. · Revista Colombiana de Reumatologia (2023) · DOI: 10.1016/j.rcreu.2021.06.001

Resumen

Clinically amyopathic dermatomyositis (CADM) is associated with antibodies directed against the protein encoded by the melanoma differentiation-associated gene 5 (MDA5). CADM patients have an increased risk of developing rapidly progressive interstitial lung disease (RP-ILD) and spontaneous pneumomediastinum. Two Peruvian cases of RP-ILD-associated CADM with spontaneous pneumomediastinum are presented, one of them was anti-MDA5 antibody positive. To our knowledge, this is the first report of anti-MDA5-associated CADM in the Peruvian population.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Científica del Sur