RAPID SPREAD OF THE EMERGING COSMOPOLITAN GENOTYPE OF DENGUE VIRUS SEROTYPE 2, AND EXPANSION OF DENGUE VIRUS SEROTYPE 1 GENOTYPE V IN PERU

Bailon H.; Jimenez V.; Galarza M.; Medrano P.; Mestanza O.; Figueroa D.; Lizarraga W.; Silva I.; Sevilla L.; Hurtado V.; Izarra V.; Padilla C.; Barcena L.; Caceres O.; Merino S.; Marcelo A.; Ruiz N.; Hapuarachchi H.C.; Sánchez C.C.; García M.P. · Revista Peruana de Medicina Experimental y Salud Publica (2024) · DOI: 10.17843/rpmesp.2024.414.13898

Resumen

Objectives. This study aimed to evaluate the prevalence and distribution of dengue virus genotype V se-rotype 1 (DENV-1) and cosmopolitan genotype serotype 2 (DENV-2) in Peru between 2019 and 2022. Materials and methods. The envelope (E) gene region was amplified from 79 serum samples by polymerase chain reaction (PCR) and sequenced by next-generation sequencing (NGS) technology. The obtained sequences were subsequently analyzed with bioinformatics tools. Results. The study generated envelope gene sequences of DENV-1 and DENV-2 serotypes. Our study revealed a rapid dispersal and wide distribution of the cosmopolitan DENV-2 genotype in several regions of Peru in 2022, as well as the spread of DENV-1 genotype V to new Peruvian regions, along with the cosmopolitan DENV-2 genotype. Conclusions. Our findings suggest the urgent need to strengthen epidemiological and genomic surveillance systems to understand and control the spread of circulating DENV genotypes in Peru. This will allow a more rapid response, as well as the monitoring of its potential dissemination to other countries in the Americas.