Prevalence of Giardia lamblia by ecoregions in Peruvian preschoolers and school-aged children: Risk stratification proposal

Cabrera R.; Whittembury A.; Terashima A. · Anales de la Facultad de Medicina (2023) · DOI: 10.15381/anales.v84i2.25351

Resumen

Introduction. Giardiasis is caused by an intestinal protozoan, Giardia lamblia. Despite its high prevalence and geographical transmission variability, there is no risk stratification tool available to prioritize interventions. Objective. To estimate the prevalence of G. lamblia in Peruvian preschoolers and schoolchildren by ecoregion from 1990 to 2018. Methods. Based on a previous meta-analysis, we conducted a G. lamblia prevalence sub-analysis by ecoregions from data of 26 studies in Peruvian preschoolers and school-aged children between 1990 and 2018. The data was extracted by district, a classification by ecoregions was made through Google Earth. Heterogeneity was analyzed using Cochrane Q test and publication bias applying the Egger method with StatsDirect version 3.2.7. The absolute risk method was performed to stratify the prevalence at district level, and 4 strata were defined based on percentiles or arbitrarily. Results. Forty-three district-level prevalence data was estimated, including 7,606 participants. The highest pooled prevalences by the randomeffects method of G. lamblia were 47.0% (95% CI: 40.0-54.0) in the Pacific desert, 27.9% (95% CI: 22.8-33.2) in the lowland forest and 26.9% (95% CI 22.5-31.5) in the Puna. Conclusions. Of every 100 preschoolers and school-aged children living in the Pacific desert, lowland forest, and in the Puna ecoregions, 47, 28, and 27 minors are infected with G. lamblia, respectively. Likewise, 4 risk strata are proposed based on prevalence: sporadic (0 to <1%), hypoendemic (1 to <25%), mesoendemic (≥25 to <50%) and hyperendemic (≥50%).

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Nacional Mayor de San Marcos; Universidad Peruana de Ciencias Aplicadas