PREVALENCE OF DYSLIPIDEMIAS IN PERUVIAN ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF HYPERCHOLESTEROLEMIA, HYPERTRIGLYCERIDEMIA, AND LOW HDL

Vera-Ponce V.J.; Zuzunaga-Montoya F.E.; Vásquez-Romero L.E.M.; Loayza-Castro J.A.; Ballena-Caicedo J.; Tapia-Limonchi R.; Gutierrez de Carrillo C.I. · Revista de la Facultad de Medicina Humana (2025) · DOI: 10.25176/rfmh.v25i4.7254

Resumen

Introduction: Dyslipidemias are a crucial risk factor for cardiovascular diseases, one of the leading causes of global morbidity and mortality. In Peru, the epidemiological transition has led to an increase in cardiometabolic risk factors; however, the prevalence of dyslipidemias has not been systematically evaluated. Objectives: To conduct a systematic review and meta-analysis to estimate the prevalence of hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterol in the Peruvian population. Methods: A comprehensive search was conducted in scientific databases and gray literature sources up to July 2024. PubMed, Scopus, Embase, and Web of Science were utilized. Observational studies reporting the prevalence of dyslipidemias in the adult Peruvian population were included. Methodological quality was assessed, random-effects meta-analyses were performed, and meta-regression analyses were conducted to explore sources of heterogeneity. Results: Twelve studies were included. The pooled prevalence was 25.93% (95% CI: 18.90-33.66%) for hypercholesterolemia, 44.76% (95% CI: 34.31-55.46%) for hypertriglyceridemia, and 56.94% (95% CI: 47.24-66.37%) for low HDL. Differences in prevalence were observed by sex, with higher prevalence of low HDL in women (66.93%) than in men (49.04%). Meta-regression analyses identified year as a significant moderator for hypercholesterolemia and hypertriglyceridemia, while sex showed no significant association; residual heterogeneity remained high across all analyses. Conclusions: There is a high prevalence of dyslipidemias in Peru. Despite the identified temporal associations, residual heterogeneity remained high, suggesting the influence of other unassessed factors. © Article published by the Revista de la Facultad de Medicina Humana of Universidad Ricardo Palma. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), which allows non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited.

Instituciones: Universidad Continental; Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas