Predictors of quality of life in OCD: Machine-derived features beyond expert consensus

Thorsson M.; Trujillo A.; Romero M.J.; Irreño-Sotomonte J.; Borda T.; Zepeda-Burgos R.M.; Martinez Mallen M.C.; Moyano B.; Anderberg J.L.; Muñoz J.S.; Moore H.C.; Frederick R.M.; Berrones D.; Cruz V.Z.; Onyeka O.; Wiese A.D.; Wagner K.M.; Adorno V.R.; Agostini V.; Aguilar W.W.; Aguirre C.; Alvarado-Quiroz V.; Ancalade N.; Anciburo M.E.; Antich A.Y.; Aponte D.; Arango Londoño J.E.; Arellano Espinosa A.A.; Arellano-Ramírez L.; Arnold P.D.; Carmelo B.A.; Atkinson E.G.; Avanesyan T.; Avery J.E.; Avila-Vazquez A.F.; Ayala J.N.; Barbieri Aguirre T.L.; Barrera C.N.; Barrero Contreras J.A.; Barry K.; Belanger A.N.; Benitez L.M.; Best J.R.; Bigdeli T.B.; Bommiasamy H.; Boyajian L.; Boyle N.; Muñoz D.B.; Burton C.L.; Buxbaum J.D.; Calderón Rivera R.E.; Callahan J.L.; Camacho Gomez C.A.; Campos Ponce L.A.; Canchari E.G.; Torres R.C.; Catano-Cedillo M.L.; Cervin M.; Chang A.; Cheng J.S.C.; Chire J.M.; Muñoz M.C.; Cicero D.C.; Cifuentes-Espinoza A.P.; Quiroz P.C.; Colombo G.M.; Comer J.S.; Condori-Apaza L.; Cortina J.; Costa C.; Crosbie J.; Cruz V.O.; Cruz I.A.; Cunning A.; Dager Perez G.J.; Dailey M.M.; Dang B.D.; Davalos Checco K.L.; Dawson A.; del Prado P.; del Río D.; Dev A.; Diaz S.; Estrada F.S.; Figueroa E.G.; Flecha L.M.; Flores-Garcia Á.M.; Franklin M.E.; Frederick R.M.; Fujita R.; Furr J.M.; Gaeta A.; Gamarra O.M.; Garay-Contreras C.; García-Bravo N.; García-Jaimes C.; Garrison S.R.; Giusti-Rodriguez P.; Galera A.G.; Gonzalez-Barrios P.; Goodman W.K.; Gorosito J.D.; Grice D.E.; Guintivano J.; Guttfreund D.G.; Halvorsen M.W.; Haslop Miles J.A.R.; Henríquez-Belmar F.; Hernandez D.G.; Hernández Núñez E.V.; Hettema J.M.; Hovey J.D.; Ccarhuas B.H.; Iturralde Pedraza S.S.; Jagannathan N.; Jensen M.; Jiwani R.B.; Johnson J.S.; Joutteaux S.; Lujambio J.A.J.; Kehrer S.; Kennedy J.L.; Lanzagorta N.; Lázaro-Muñoz G.; Longhurst M.; Lozada Martinez D.A.; Luna E.S.; MacLellan A.; Marques Horvath A.H.; Martinez M.; Martínez G.N.; Martinez-Gonzalez K.G.; de Los Angeles Matos M.; Mattheisen M.; McCarty R.J.; McGuire J.F.; McKay D.; McOmber C.; Melendez de Borja N.E.; Minaya C.; Miño T.; Mithani S.M.; Zambrana M.M.; Morales-Rivero A.; Moya P.R.; Moyano M.B.; Mukunda P.; Muñoz Zabaleta M.J.; Nicolini H.; Núñez Bracho A.A.; Núñez Bracho B.E.; Obando D.; Ochoa M.E.; Ochoa-Panaifo M.E.; O'Higgins M.; Olavarria Castaman L.A.; Balmaceda T.O.; Olmedo Tobar M.J.; Ortega I.; Paredes-Linares V.S.; Pato M.T.; Pavlinusich I.; Miño M.P.Y.; de Leon E.P.; Perales Orellana J.L.; Pereira S.; Duarte T.P.; Phan A.; Placencia M.; Ponce L.; Poovey K.; Qiao T.; Quiroz-Padilla M.F.; Quispe-Correa M.F.; Ramirez Heros A.S.; Ramírez Valencia D.A.; Ramos R.T.; Ramos I.C.; Ramsey K.A.; Rancourt D.; Gomez S.R.; Reyes Espinosa R.C.; Reyes-Parada M.; Richter P.; Rodriguez C.I.; Barajas S.R.; Ruggero C.J.; Ruiz-Chow A.; Sagarnaga M.N.; Salazar Montoya G.N.; Salhadar N.; Schachar R.J.; Segovia L.M.; Seligman L.D.; Siegel I.J.; Spencer S.D.; Stewart S.E.; Tames-Bravo M.J.; Tapia-Cuevas V.; Thompson P.M.; Timpano K.R.; Tonarelli S.; la Garza B.T.-D.; Trujillo A.; Villar C.U.; Jardón C.V.; Valentine K.; Vallejo-Silva A.; van Roessel P.; Vargas-Medrano J.; Vásquez-Suyo M.I.; Vergara M.V.; Vidal-Martinez G.; Vilchez Huaman M.V.; Vollaro C.; Wilkerson S.; Zai G.; Zappa L.M.; Zoghbi A.W.; Albuquerque N.G.; Alves G.S.; Alves-Pereira R.; Artiga L.M.S.; Azevedo J.P.; Barbosa I.G.; Bortoncello C.F.; Cappi C.; Carneiro B.A.; Christo R.B.; Costa D.L.C.; Cupertino F.; de Mathis M.A.; de Menezes G.B.; Dib L.; Diniz M.J.A.; do Rosário M.C.; Dreher C.B.; Félix-da-Silva C.; Ferrão Y.A.; Ferreira G.M.; Ferreira L.C.; Fontenelle L.F.; Frota G.A.; Gil M.L.W.; Guarinon I.G.; Hoexter M.Q.; Hounie A.G.; Lima M.O.; Martinho A.F.; Aguiar T.M.; Merces J.V.R.; Miguel E.C.; Muniz A.; Oliveira B.S.R.; Passinho J.S.; Quarantini L.C.; Quarantini-Alvim Y.; Ramos V.R.; Sampaio A.S.; Saraiva L.C.; Shavitt R.G.; Silva O.A.F.S.; Soares M.; Souza V.S.; Stumpf B.P.; Tavares H.; Crowley J.J.; Storch E.A.; Cervin M. · Comprehensive Psychiatry (2026) · DOI: 10.1016/j.comppsych.2026.152737

Resumen

Background: Quality of life (QoL) varies substantially among individuals with obsessive–compulsive disorder (OCD), but the clinical and contextual factors most strongly associated with QoL remain unclear. A better understanding of these factors may improve assessment, treatment planning, and service organization. Methods: 3152 adults with lifetime OCD completed a validated measure of QoL along with clinical and sociodemographic measures. A 22-feature expert-informed model, based on prior scientific and clinical knowledge, was compared with data-driven models using recursive feature elimination and gradient-boosted trees. Model performance was evaluated using 5-fold cross-validation. Results: Data-driven models modestly outperformed the expert-informed model (RMSE 7.23 vs. 7.56; R2 0.55 vs. 0.51). Although several predictors overlapped, machine-derived models identified predictors not selected by experts, including subjective social rank, anhedonia, and inequality-adjusted national human development. Across models, depression severity, subjective social rank, and anxiety severity were the strongest predictors of QoL. Reduced data-driven models using 12–18 features retained comparable predictive performance and significantly outperformed the expert model. Conclusions: Expert knowledge captured much of the variance in QoL in OCD, but data-driven approaches improved predictive accuracy and identified novel factors. QoL was most strongly predicted by depression severity, anxiety severity, and social context rather than OCD severity alone, suggesting that clinical assessment and treatment planning should routinely consider broader affective and psychosocial difficulties alongside OCD symptoms.

Instituciones: Universidad Nacional Mayor de San Marcos; Universidad de San Martín de Porres; Universidad Nacional Autónoma de Alto Amazonas; Universidad Privada del Norte