Postulating the possible cellular signalling mechanisms of antibody drug conjugates in Alzheimer's disease

Punyakoti P.; Behl T.; Sehgal A.; Yadav S.; Sachdeva M.; Anwer M.K.; Vargas-De-La-Cruz C.; Venkatachalam T.; Naqvi M.; Verma R.; Tuli H.S. · Cellular Signalling (2023) · DOI: 10.1016/j.cellsig.2022.110539

Resumen

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the world. Although the basic pathology of the disease is elucidated, it is difficult to restore or prevent the worsening of neurodegeneration and its symptoms. Antibody and small molecule-based approaches have been studied and are in study individually, but a combined approach like conjugation has not been performed to date. The conjugation between antibodies and drugs which are already used for Alzheimer's treatment or developed specifically for this purpose may have better efficacy and dual action in mitigating Alzheimer's disease. A probable mechanism for antibody-drug conjugates in Alzheimer's disease is discussed in the present review.

Instituciones: Universidad Nacional Mayor de San Marcos; Universidad de Ciencias y Humanidades