PERIPHERAL PNET OF THE INGUINAL REGION WITH FAVORABLE RESPONSE TO NEOADJUVANT QT-THALIDOMIDE

Aliaga-Chávez R.; Torvisco-Inca L.D. · Revista de la Facultad de Medicina Humana (2024) · DOI: 10.25176/rfmh.v24i4.6611

Resumen

Introduction: PNETs are neoplasms derived from the neural crest. They are classified into: 1) central PNET, 2) neuroblastoma and 3) peripheral PNET. The objective is to report the case of a 32-year-old female patient with an inguinal tumor with immunohistochemical profile compatible for PNET treated with chemotherapy and induction thalidomide. Clinical case: 32-year-old female patient presented with a tumor in the inguinal region, the biopsy indicated: round cell neoplasm with small nuclei, hyperchromatic and monomorphous; the immunohistochemical profile was synaptophysin positive, neurofilament positive, SOX-11 positive and Ki-67: 70%, induction chemotherapy was started with carboplatin- etoposide and thalidomide achieving a 60% reduction in tumor size, followed by compartmentectomy with regional lymphadenectomy and later adjuvant radiotherapy and maintenance chemotherapy. Conclusions: In this patient, multidisciplinary treatment for pPNET benefited from the use of chemotherapy and thalidomide in the induction phase.

Instituciones: Universidad Ricardo Palma