Ovarian reserve and pregnancy prognosis in vitro fertilization

Vargas-Tominaga L.; Guerra Y.; Medina A.; Vargas A.; Vargas P.; Vargas N.; Miranda D.; Huillca F.; Gómez M. · Revista Peruana de Ginecologia y Obstetricia (2025) · DOI: 10.31403/rpgo.v71i2733

Resumen

Introduction: The woman’s age and ovarian reserve are the most important factors in fertility treatment. Ovarian reserve can be calculated through antral follicle count (AFC) with vaginal ultrasound, providing valuable information on the pregnancy prognosis in assisted reproduction. Objective: To defne the signifcance of AFC in the pregnancy prognosis in in vitro fertilization. Methods: Retrospective observational study in which the clinical records of 508 infertile patients who underwent in vitro fertilization at the Centro de Fertilidad y Ginecología del Sur from December 2005 to April 2024 were reviewed. The clinical pregnancy rate in women with AFC 5 and in those with AFC 5 is analyzed and compared with the diferences found according to age. Results: The clinical pregnancy rate in women with AFC 5 was 35.2%, while it was 14.3% in women with AFC < 5 (p = 0.0236), and was 41.9% in patients < 35 years and 27.2% in those 35 years (p = 0.0005). Diferences in clinical pregnancy rate are more transcendent when considering AFC rather than age (Odds Ratio: 3.3 versus 1.9, respectively). Conclusions: Patients with AFC < 5 have three times lower clinical pregnancy rate in IVF than those with greater ovarian reserve.