Outpatient management of uncomplicated ectopic pregnancy with oral methotrexate

Guerrero-Leonardo Ú.J. · Revista Peruana de Ginecologia y Obstetricia (2025) · DOI: 10.31403/rpgo.v71i2782

Resumen

Background. Ectopic pregnancy is a significant cause of maternal morbidity in the first trimester. Although intramuscular methotrexate is the standard medical treatment, the oral route has emerged as an alternative in outpatient settings with logistical limitations. Objective. To describe the experience in the outpatient management of uncomplicated ectopic pregnancy with oral methotrexate in a gynecological center. Materials and methods. Observational, descriptive, and retrospective study. Ten patients were included, all treated with oral methotrexate (1 mg/kg every 8 hours for two days). Results. The mean age was 27.8 years (range 21–35). All patients met the criteria for early response (>15% decrease on day 4 and <50 mIU/mL on day 7) and achieved complete β-hCG negativization during follow-up, without adverse events or need for additional doses or surgery. Conclusions. Outpatient use of oral methotrexate was effective and safe in selected patients.