Outcomes of sleeve gastrectomy and Roux-en-Y gastric bypass in patients with liver disease and body mass index ≥ 40: analysis using the 2023 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database

Sebastian R.; Zevallos A.; Tuesta O.; Riva A.; Biller J.; Adrales G.; Li C.; Schweitzer M. · Surgery for Obesity and Related Diseases (2026) · DOI: 10.1016/j.soard.2026.06.001

Resumen

Background: Nonalcoholic fatty liver disease (NAFLD), prevalent in bariatric surgery patients, is a leading indication for liver transplantation. However, class III obesity is a relative contraindication for transplantation. Objective: To evaluate the safety of bariatric surgery in patients with mild to moderate liver disease of any cause. Setting: 2023 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database. Methods: Patients who underwent sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) were included. We performed a 1:1 propensity score matching analysis with 27 preoperative characteristics. We compared 30-day postoperative outcomes for patients with body mass index (BMI) < 40 with versus without liver disease after SG (Analysis 1) or RYGB (Analysis 2) and for patients with BMI ≥ 40 with versus without liver disease after SG (Analysis 3) or RYGB (Analysis 4). Results: From 182,673 patients (71% SG; 29% RYGB), outcomes in analysis 1 showed that patients with liver disease are associated with higher rates of surgical site infection (SSI), and blood transfusions (P < .05). Analysis 2 showed that patients with liver disease are associated with higher rates of emergency visits, readmissions, reoperations, and SSI (P < .05). In analysis 3, patients with liver disease had higher rates of unplanned intensive care unit admission, emergency visits, SSI, blood transfusions, and readmissions (P < .05). In analysis 4, patients with liver disease had higher rates of emergency visits and SSI (P < .05). However, there were no differences across the four analyses in mortality and cardiopulmonary complications. Conclusion: Bariatric surgery in patients with liver disease is safe and feasible with similar mortality and cardiopulmonary complications compared to patients without liver disease. However, patients with liver disease have a higher rate of complications, including emergency visits, SSI, readmissions, and blood transfusions after bariatric surgery. Furthermore, patients with liver disease and BMI ≥40 have higher rates of unplanned intensive care unit admission, emergency visits, readmissions, and reoperations.

Instituciones: Universidad Científica del Sur