OPTIMAL ANTIMICROBIAL USE AND CLINICAL CURE IN URINARY TRACT INFECTION DUE TO BETA-LACTAMASE-RESISTANT ESCHERICHIA COLI AT A TERTIARY HOSPITAL IN NORTHERN PERU

Rosales-Cruzalegui K.M.; Polo-Vidal L.E.; Alpaca-Salvador H.A. · Revista de la Facultad de Medicina Humana (2026) · DOI: 10.25176/rfmh.v26i2.7978

Resumen

Introduction: The association between the implementation of an Antimicrobial Stewardship Program (ASP) and clinical cure was evaluated in hospitalized patients with urinary tract infection (UTI) caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. A retrospective cohort study was conducted at Hospital III EsSalud-Chimbote, including a cohort of 18 patients not exposed to the ASP and 34 exposed patients. The overall clinical cure rate was 86.5%. In the multivariable model using Firth's penalized logistic regression, the ASP was not associated with clinical cure, with an adjusted odds ratio (aOR) of 0.37 (95% CI: 0.03–2.35; p=0.309). Female sex was associated with a higher likelihood of clinical cure, with an aOR of 7.32 (95% CI: 1.39–51.96; p=0.019). In conclusion, exposure to the ASP was not significantly associated with clinical cure in hospitalized patients with UTI caused by ESBL-producing E. coli. Article published by the Revista de la Facultad de Medicina Humana of Universidad Ricardo Palma. It is an open access article, distributed under the terms of the Creative Commons License: Creative Commons Attribution 4.0 International, CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/), which allows non-commercial use, distribution and reproduction in any medium, provided that the original work is duly cited. For commercial use, please contact revista.medicina@urp.edu.perevista

Instituciones: Universidad Nacional del Santa