Saltar al contenido
República del Perú · Observatorio de la producción científica universitaria
OApol.org Observatorio de Inteligencia Científica Universitaria del Perú
OApol.org
Inicio Universidades Publicaciones Investigadores
Repositorios
Tesis y trabajos académicosRevistas
Indicadores
Ranking trimestralRanking por carreraObjetivos de Desarrollo SostenibleReporte OCDERed neuronal 3D
Acerca
MetodologíaPrivacidad

Nutritional characterization of Cusco green tea and its synergistic effect with omega-3 on metabolic and cognitive dysfunctions in obese rats

Finetti-Casanova P.; Bernuy-Osorio N.; Rodriguez-Pozo M.; Maaloul A.; Abdala-Diaz R.T.; Decara J. · Journal of the Science of Food and Agriculture (2026) · DOI: 10.1002/jsfa.70623

Resumen

BACKGROUND: Obesity and its metabolic complications, such as insulin resistance and cognitive decline, remain a global health challenge. Green tea (Camelia sinensis) and ω-3 polyunsaturated fatty acids (PUFAs) are recognized for their antioxidant, anti-inflammatory, and neuroprotective properties. This study aimed to qualitatively characterize green tea from Cusco, Peru, and evaluate the synergistic effects of its infusion (GTi) and ω-3 supplementation on hyperlipidemia, proinflammatory cytokines, and cognitive impairment in a high-fat diet (HFD) rat model. RESULTS: Nutritional analysis confirmed the high quality of Cusco green tea, showing potent antioxidant activity and a unique catechin profile. In obese rats, HFD induced significant weight gain and metabolic dysfunction; supplementation with GTi, ω-3, or their combination significantly improved glucose tolerance and reduced triglyceride and very-low-density lipoprotein levels. Notably, the combined treatment (GTi + ω-3) showed the greatest reduction in plasma TNF-α. Behavioral assessments via novel object recognition tests demonstrated that supplementation alleviated obesity-related cognitive deficits, significantly enhancing both short-term and long-term memory discrimination indices. CONCLUSION: This study highlights the potential of combining Cusco green tea and ω-3 PUFAs as a complementary nutritional intervention to mitigate hyperlipidemia and cognitive dysfunction associated with obesity. These effects are likely mediated through the modulation of proinflammatory mediators and the enhancement of antioxidant defenses, which help restore redox homeostasis and protect neuronal integrity.

Instituciones: Universidad Nacional Agraria La Molina