New Cyclopeptide and γ-Butyrolactone Derivatives from an Endophytic Strain of Cophinforma mamane

Litot C.; Vansteelandt M.; Ortiz S.; Barakat F.; Crossay E.; Titton D.; Bourgeade-Delmas S.; Amasifuen C.; Graton J.; Jacquemin D.; Stigliani J.-L.; Haddad M.; Fabre N. · ACS Omega (2025) · DOI: 10.1021/acsomega.5c01292

Resumen

From an endophytic strain of Cophinforma mamane isolated from the leaves of Bixa orellana, a previously undescribed γ-butyrolactone compound (2) and three new cyclopentapeptides (3-5) have been isolated from the same strain, along with the known (4R)-striatisporolide A (1). Their structures were elucidated through extensive spectral analysis and DP4+ calculations. The two γ-butyrolactone derivatives (1, 2) exhibited moderate inhibitory activity against axenic Leishmania infantum amastigotes (IC50 = 13.33 and 4.43 μM, respectively), while only compound 2 displayed cytotoxic activity on Jurkat cells (17% growth inhibition at 1 μg/mL) and weak antibacterial activity against Enterococcus faecalis (MIC = 64 μg/mL).

Instituciones: Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas