Nephroprotective effect of Opuntia ficus indica purple variety fruit juice in rats induced to renal damage by gentamicin

Villanueva-Huallpa J.A.; Gallo Ruelas M.; Huamán-Gutierrez O.G. · Nutricion Clinica y Dietetica Hospitalaria (2025) · DOI: 10.12873/451villanueva

Resumen

Introduction: Chronic Kidney Disease (CKD) has become a silent epidemic affecting about 10% of the world’s population, the discovery of new protective functional foods is important to hinder the development of this disease. Objective: Evaluate the nephroprotective effect of fruit juice of Opuntia ficus indica purple variety in rats induced by renal damage by gentamicin. Methods: 32 male Holtzman rats were involved in the experiment; we used the fruit juice of Opuntia ficus indica purple variety to test its nephroprotective properties. The rats were randomized into four groups (n = 8). Which were treated orally for 27 days with the following: Group I and II-1 ml / kg of physiological serum; Group III-20 ml / kg of Opuntia ficus indica juice (OJ); Group IV-40 ml / kg of OJ. From day 21, Group II to IV received intramuscular gentamicin at a dose of 50 mg/kg for 7 days. Results: The administration of 40 ml/kg of Opuntia ficus indica evidenced a statistically significant decrease of serum creatinine, urea, uric acid and urine proteins, histologically, we observed a conserved structure at the level of the glomerulus, capsule of Bowman and a slight desquamation of the level of the proximal and distal tubules. Conclusion: The juice of Opuntia ficus indica purple variety at a dose of 40 ml / kg exerted a nephroprotective effect in the renal tissue with the improvement of the biochemical parameters and the histological study.

Instituciones: Universidad Nacional Mayor de San Marcos