Myasthenia gravis and pregnancy: impact and approach

Alfaro-Paredes K.; Aguilar-Ydiáquez C.; Aguirre-Flores R.; Schulz-Cáceres H. · Revista de Neurologia (2022) · DOI: 10.33588/rn.7505.2022207

Resumen

Introduction. Myasthenia gravis is characterized by skeletal muscle weakness, the most common initial presentation includes ocular weakness with asymmetric ptosis and binocular diplopia. Around 19-50% of pregnant women with myasthenia gravis will experience a worsening of the disease. The objective of this article was to review the current information regarding the interrelation between MG and pregnancy; as well as its approach. Development. Bibliographic search in databases such as PubMed, ScienceDirect, SciELO, Google Scholar and medRxiv. Original articles, reviews, series and case reports between 2013 and 2022 are included. Conclusions. Myasthenia gravis would not significantly effects on pregnancy; however, pregnancy can exacerbate the disease, especially during the first trimester or after delivery. The approach to pregnant women with myasthenia gravis must be multidisciplinary and involves the adjustment of pharmacological treatment and constant monitoring.

Instituciones: Universidad Nacional de Trujillo