Multidrug-Resistant Profile of Methicillin-Resistant Staphylococcus pseudintermedius in Dogs with Pyoderma in Lima, Peru

Tomás J.; Rivas B.; Palomino-Farfán J.; Siuce J. · World's Veterinary Journal (2025) · DOI: 10.54203/scil.2025.wvj112

Resumen

Methicillin resistance is a major global health concern, and recently, methicillin-resistant Staphylococcus pseudintermedius (MRSP) has emerged as a significant issue in veterinary medicine, with the potential to spread to humans. The present study aimed to analyze Staphylococcus pseudintermedius (S. pseudintermedius) strains isolated from 585 canine pyoderma samples from 2016 to 2024 at the Faculty of Veterinary Medicine, National University of San Marcos, Peru. The mecA gene was detected by conventional polymerase chain reaction, and antimicrobial susceptibility test included seven antibiotic families, including tetracyclines, sulfonamides, aminoglycosides, second-generation cephalosporins, penicillins, fluoroquinolones, and lincosamides. Out of 585 samples, 143 (24.4%) were positive for the mecA gene, confirming the presence of MRSP. Among these strains, 107 (74.8%) were multidrug resistant (MDR), and 119 (83.2%) exhibited phenotypic oxacillin resistance. The highest resistance rates of the S. pseudintermedius carrying the mecA gene were observed for lincosamides (86.0%), cephalosporins (78.3%), and sulfonamides (76.9%), whereas resistance to amoxicillin-clavulanate was the lowest (6.3%). In addition, two isolates were resistant to all the antibiotic families evaluated. These findings underscored the increasing prevalence of MRSP and MDR S. pseudintermedius, highlighting the need for improved antibiotic protocols in veterinary medicine to mitigate resistance and ensure effective treatment strategies for canine pyoderma. © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

Instituciones: Universidad Nacional Mayor de San Marcos