Multi-Sensor Wearable Platform for Multi-Modal Physiological Parameter Extraction in Dengue

Pilar Moscol Albanil I.D.; Lavorgna V.; Saroli V.; Tomarchio V.; Chinguel C.; Ojeda C.; Castillo G.; Presti D.L.; Schena E. · Conference Proceedings - 2026 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd4.0 and IoT 2026 (2026) · DOI: 10.1109/metroind4.0iot69397.2026.11653147

Resumen

Continuous monitoring of hemodynamic alterations associated with dengue progression remains challenging due to the absence of wearable systems capable of extracting robust multi-parametric vascular markers. This study presents a multi-sensor wearable platform enabling beat-by-beat extraction of heart rate (HR), pulse arrival time (PAT), augmentation index (AIx), normalized perfusion index (PInorm), and breath-by-breath respiratory rate (BR) from synchronized physiological signals with commercial sensors. A controlled cardio-respiratory protocol was conducted in a healthy volunteer to evaluate signal integrity, physiological responsiveness, and parameter feasibility. Clear phase-dependent modulation was observed. HR increased from 85.77 bpm during normal breathing (NB) to 93.64 bpm during apnea and 92.83 bpm during fast breathing (FB). PAT shortened from 168 ms (NB) to 136 ms (FB), suggesting increased sympathetic vascular tone. PInorm, normalized to NB baseline (100%), decreased to 60.03% during apnea and 79.01% during FB, approaching the predefined vasoconstriction threshold. AIx became less negative during apnea (-14.35%) compared to NB (-15.28%), and more negative during FB (-18.36%), reflecting dynamic modulation of wave reflection and peripheral resistance. Respiratory rate increased from 15.3 brpm (NB) to 26.8 brpm (FB), confirming protocol compliance. These findings demonstrate the technical feasibility of extracting vascular resistance, wave reflection, perfusion, and cardio-respiratory coupling markers from a wearable platform under controlled physiological perturbations. Although limited to a single healthy subject, this preliminary study supports the potential of continuous, non-invasive multi-parametric monitoring to track vascular and autonomic alterations relevant to dengue pathophysiology. Future studies will evaluate larger cohorts, including dengue patients, to determine whether longitudinal trends in these parameters can enable early detection of transitions toward a possible critical phase characterized by altered peripheral resistance and hemodynamic instability.

Instituciones: Universidad de Piura