Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report

Farfán-Chávez L.G.; Pérez-Acuña Medina K.A. · Revista del Cuerpo Medico Hospital Nacional Almanzor Aguinaga Asenjo (2023) · DOI: 10.35434/rcmhnaaa.2023.161.1645134

Resumen

Background: Tuberculosis is one of the 10 leading causes of death worldwide. In 2020, it caused 1.5 million deaths. It is estimated that it reached 10.0 million new cases during the same year. Case of report: 93-year-old male, history of pulmonary TB 15 years ago and current TB contact. He presented dyspnea and pleuritic pain for 4 months. Thoracocentesis concludes exudate, pleural biopsy compatible with non-caseating granulomatous pleurisy. Receive antituberculosis regimen, developing hepatic RAFA. Pharmacological challenge is performed to design a new treatment scheme. Patient manages to recover. It is concluded that the management of tuberculosis should be individualized. © Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Instituciones: Universidad Nacional Mayor de San Marcos