Methicillin-Resistant Staphylococcus aureus Bloodstream Infections in Hospitalized Patients in Peru

Garcıa C.; Hinostroza N.; Gordillo V.; Inchaustegui M.L.; Astocondor L.; Chincha O.; Alejos S.; Olivera M.; Bojorquez-Fernandez D.; Concha-Velasco F.; Vasquez N.; Castaneda-Sabogal A.; Sullon P.; Fernandez V.; Villegas-Chiroque M.; Lopez E.; Hueda-Zavaleta M.; Vidaurre A.; Bocangel C.; Barco E.; Paricahua E.; Zervos M.; Jacobs J.; Krapp F. · American Journal of Tropical Medicine and Hygiene (2023) · DOI: 10.4269/ajtmh.23-0054

Resumen

There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017–2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non–PantonValentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)—SCCmec IV, PVL-producer—(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Nacional Daniel Alcides Carrión; Universidad Nacional de San Antonio Abad del Cusco; Universidad Privada Antenor Orrego; Universidad Privada de Tacna