Metachronous gastric adenocarcinoma following gastric lymphoma treated with chemotherapy and radiation therapy

Bolaños F.B.; Palma E.M.; Velit C.B.; Cordova R.Q.; del Pilar Bravo Taxa M. · Horizonte Medico (2025) · DOI: 10.24265/horizmed.2025.v25n1.16

Resumen

Gastric cancer ranks fifth in both incidence and mortality worldwide, according to the report from the Global Cancer Observatory (Globocan) as of 2022 (1). When discussing the global gastric cancer report, it is assumed that it refers to adenocarcinoma. However, it should be pointed out that the most frequent histological types of gastric cancer are adenocarcinoma and lymphoma, the former being the most frequent on average, accounting for over 95 % of all gastric neoplasms (2). In Peru, the Lima Metropolitan Cancer Registry ranked gastric cancer as the third most frequent and the leading cause of mortality for both sexes (3). On the other hand, the synchronous or metachronous diagnosis of these types of gastric cancer, such as adenocarcinoma and lymphoma, is rare. Metachronous cancer, or second primary cancer, is defined as a new tumor that occurs more than six months after the diagnosis of the first neoplasm, but is not caused by the dissemination or recurrence of the previous tumor (4). For these reasons, and pertinently, we present the case report of a 57-year-old female patient diagnosed with primary gastric lymphoma, treated with a combination of radiation therapy and chemotherapy with curative intent. Thirteen years later, at the age of 70, she was diagnosed with gastric adenocarcinoma during a follow-up endoscopy, which was managed surgically. The case is detailed below, along with a review of the relevant literature. Copyright