Mesenteric thrombosis associated with Sars-Cov-2 infection

Caballero-Alvarado J.; Vargas Á.Á.; Zviaguina I.H.; Vargas A.I.; Barboza J.J.; Peralta K.L. · Boletin de Malariologia y Salud Ambiental (2022) · DOI: 10.52808/bmsa.7e6.622.006

Resumen

COVID-19 disease is mainly characterized by respiratory clinical manifestations, which can be light to very severe; however, there is a group of patients who can present with thromboembolic events in any part of the body. A search of scientific information in three databases, PubMed, Scopus and Web of Science, was carried out with the aim of describing and analyzing the potential causes of mesenteric thrombosis associated with SARSCoV-2 infection, as well as the clinical outcomes of patients who presented and were treated for mesenteric thrombosis during the course of the disease. Different pathophysiological mechanisms of thromboembolic events associated with COVID-19 have been reported, among them the hyper-coagulable state, an increased production of Von Willebrand factor, the expression of angiotensin-converting enzyme 2 in small intestinal enterocytes, which in response to infection can release inflammatory mediators, and the state of shock present in two thirds of critically ill patients. Patients with COVID-19 and especially those with severe stages may have different mechanisms that converge or exacerbate a state of hyper-coagulation, which can affect any part of the body such as the mesenteric vessels and lead to gastrointestinal ischemia that compromises its viability and ends in intestinal resection due to necrosis.

Instituciones: Universidad Privada Antenor Orrego; Universidad Señor de Sipán