Maternal erythrocytosis as a risk factor for small for gestational age at term in high altitude

Villamonte-Calanche W.; Salazar-Zegarra M.A.; De-La-torre-dueñas C.; Villamonte-Jerí A.; Vera-Luza A.; Bustinza-Apaza M.H.; Huanca-Huirse N. · Revista Brasileira de Ginecologia e Obstetricia (2024) · DOI: 10.61622/rbgo/2024rbgo98

Resumen

Objective: To determine if maternal erythrocytosis is a risk factor for small-for-gestational age at term at 3,400-m altitude in pregnant women without intercurrent disease. Methods: Analytical study of retrospective cohorts at Cusco, a city at 3,400-m altitude. Our participants were 224 and 483 pregnant women with and without exposure to maternal erythrocytosis, respectively. A logistic regression with the goodness of fit to the proposed model was also performed with the Hosmer and Lemeshow test, evaluating the small-for-gestational-age results with or without exposure to hemoglobin >14.5 g/dl. Results: The incidence of small-for-gestational-age was 6.9% for this entire cohort. The maternal erythrocytosis during gestation without any maternal morbidity at 3,400-m altitude has an ORa=0.691 (p=0.271) for small-for-gestational-age at term. Inadequate prenatal control has an ORa=2.115 (p=0.016) for small-for-gestational-age compared to adequate prenatal control. Conclusion: Maternal erythrocytosis in pregnant women without any morbidity is not a risk factor for small-for-gestational-age at 3,400 m-altitude.

Instituciones: Universidad Nacional de San Antonio Abad del Cusco; Universidad Andina del Cusco