Managing Necrotizing Soft-Tissue Infection in Breast Cancer: A Case of Emergency Toilet Mastectomy

Farzan J.J.; Guart J.A.; Kulkarni N.; Roberts S.; De La Cruz-Ku G.; Czerniach D.R.; Dinh K.H. · American Journal of Case Reports (2025) · DOI: 10.12659/ajcr.946669

Resumen

Patient: Final Diagnosis: Symptoms: Clinical Procedure: — Specialty: Oncology • Surgery Female, 71-year-old High grade invasive ductal carcinoma • ER/PR-positive • HER2-negative with superimposed necrotizing soft tissue infection Fungating right breast mass Objective: Background: Case Report: Conclusions: Rare disease This case report presents a rare instance of advanced breast cancer presenting with superimposed necrotizing soft-tissue infection (NSTI) and sepsis, uniquely managed with an emergency toilet mastectomy. Toilet mas-tectomies have become increasingly rare and controversial in modern surgical oncology and are generally limited to palliative indications. This report contributes to the limited literature on NSTI of the breast in the setting of malignancy and highlights the potential utility of toilet mastectomy as a palliative option for carefully selected patients with advanced breast cancer complicated by infection. A 71-year-old woman presented with a large fungating right breast mass after 50 years of receiving no health care. She was septic, with clinical signs of NSTI. Emergency surgical intervention involved a toilet mastectomy with extensive debridement. Histopathological analysis confirmed high-grade invasive ductal carcinoma of the breast with skin involvement, ER/PR-positive, HER2-negative, pT4bN0Mx. Cultures were consistent with type 1 NSTI. The postoperative course was complicated, requiring prolonged ICU care, multiple debridements, and advanced wound management. Significant complications included septic shock, acute kidney injury, and wound dehiscence. This case is notable for 3 key aspects: (1) NSTI and sepsis are rare but serious complications of advanced breast cancer, underscoring the need for clinicians to maintain a high index of suspicion for this condition; (2) timely and aggressive management of NSTI, regardless of its association with underlying malignancy, is critical for re-ducing morbidity and mortality; and (3) toilet mastectomy, although less commonly performed today, remains an appropriate palliative intervention in select cases. © Am J Case Rep, 2025; 26: e946669.

Instituciones: Universidad Científica del Sur