Lipschütz acute vulvar ulcer related to COVID-19 vaccination: First case report in South America

Sangster-Carrasco L.; Paz-Temoche R.; Coronado-Arroyo J.; Concepción-Zavaleta M.; Roseboom P.; Concepción-Urteaga L.; Zavaleta-Gutiérrez F. · Medwave (2023) · DOI: 10.5867/medwave.2023.02.2674

Resumen

Lipschütz ulcer is a non-sexually transmitted genital lesion of unknown etiology, which pres-ents as a painful vulvar ulcer. Lipschütz ulcers have been described in most continents. This is the first case reported in Peru and South America. We present the case of a 33-year-old female patient with a Lipschütz ulcer after being vaccinated with the second dose of the AstraZeneca COVID-19 vaccine. She reported having had only one sexual partner in her lifetime. Laboratory results were negative for herpes simplex 2, Cytomegalovirus, Toxoplasma gondii, Epstein-Barr virus, and syphilis. The patient received symptomatic treatment. Ten days after the onset, the patient was significantly better during follow-up. This case report displays a potential adverse effect of the AstraZeneca COVID-19 vaccine as a Lipschütz ulcer triggered by the host humoral immune response. However, further research is needed to establish the causal relationship between these two.

Instituciones: Universidad Peruana de Ciencias Aplicadas; Universidad Nacional de Trujillo