Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis

Ulloque-Badaracco J.R.; Hernandez-Bustamante E.A.; Cabrera-Guzmán J.C.; Delgado-Raygada J.E.; Dotto-Vasquez G.; Maldonado-Basurto G.F.; Figueroa-Larragán A.A.; Trujillo-Jurado K.Z.; Evaristo-Ballmann G.; Flores-Gavino A.; Herrera-Añazco P.; Benites-Zapata V.A. · Therapeutic Advances in Endocrinology and Metabolism (2025) · DOI: 10.1177/20420188251397203

Resumen

Background: Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and prevalent endocrine-metabolic condition. Objectives: This study aims to synthesize the available evidence on the comparison of lipid accumulation product (LAP) and visceral adiposity index (VAI) in women with and without PCOS. Design: Systematic review and meta-analysis. Data sources and methods: A systematic search was executed across five electronic databases. Continuous variables were assessed using the standardized mean difference (SMD) and its 95% confidence interval (CI). Results: A total of 46 studies were included (n = 12,442). PCOS patients have higher values of LAP (n = 10,658; SMD: 0.65; 95% CI: 0.47–0.83, p < 0.05; I2 = 93.65%) and VAI (n = 7930; SMD: 0.53; 95% CI: 0.21–0.85; p < 0.05; I2 = 97.24%) compared to those without the syndrome. Conclusion: Women with PCOS show significantly higher VAI and LAP values than those without this syndrome. © The Author(s), 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Instituciones: Universidad Peruana de Ciencias Aplicadas; Universidad Nacional de Trujillo; Universidad Científica del Sur; Universidad San Ignacio de Loyola; Universidad Nacional Federico Villarreal