Kidney involvement in multiple myeloma: two cases report

Vizcarra-Vizcarra C.A.; Zúñiga-Morales F.M.; Zegarra-Chilo A.N.; Cornejo-Perea M.M.; Velarde-Mamani M.F.; Serrano-Gutiérrez D.C. · Revista Cubana de Hematologia, Inmunologia y Hemoterapia (2026)

Resumen

Introduction: Multiple myeloma is a neoplasm of plasma cells that usually presents with kidney failure, anemia, bone pain, and hypercalcemia; however, it can also have other clinical manifestations, such as nephrotic syndrome or acute kidney injury. Objective: To describe two cases of multiple myeloma and renal involvement, demonstrated by kidney biopsy, with different clinical presentations. Case presentation: The first case was a 53-year-old male patient who presented with anemia and increased creatinine, required dialysis, did not present hypercalcemia, and underwent bone marrow aspiration with 60% plasma cell infiltration. The second case was a 70-year-old female patient who presented with edema and proteinuria, who underwent a kidney biopsy that reported light chain amyloidosis and was subsequently diagnosed with multiple myeloma. Conclusions: Multiple myeloma can manifest as myeloma cast nephropathy or AL amyloidosis, so a kidney biopsy is important for diagnosis and treatment.

Instituciones: Universidad Católica de Santa María