Juglans regia L.: Source of Bioactive Compounds with Potential Anticancer Activity

Requejo-Rodríguez C.Y.; Roncal-Alayo E.M.; Silva-Correa C.R.; Villarreal-La Torre V.E.; Sagástegui-Guarniz W.A.; Gamarra-Sánchez C.D.; Janampa-Castillo W.E.; Alvarez-Trujillo J.E.; Vela-Urbina G.J.; Calderón-Peña A.A.; Aspajo-Villalaz C.L.; Cotrina-León M.E.; Castañeda-Carranza J.A.; Dionicio-Rosado D.Y. · Pharmacognosy Journal (2024) · DOI: 10.5530/pj.2024.16.161

Resumen

Background: Juglans regia L., commonly known as “walnut”, belongs to the Juglandaceae family, with antioxidant, anti-inflammatory, and hypoglycemic medicinal properties. Objective: Describe the anticancer potential of the bioactive compounds present in Juglans regia L. Method: Recent scientific studies were reviewed on the effects of bioactive compounds from Juglans regia L. on inhibiting tumor growth and cancer development in several experimental models. To do this, a scientific literature search was carried out, using databases such as PubMed, Scopus, and Science Direct. Results: Regarding the selected articles, it was found that some bioactive compounds from Juglans regia L. exhibit mechanisms of anticancer action, among which the following stand out: induction of apoptosis, suppression of angiogenesis, and modulation of cell signaling pathways related to cell proliferation and survival. Conclusion: It is concluded that Juglans regia L. contains active metabolites with potential anticancer effects.

Instituciones: Universidad Nacional de Trujillo; Universidad Nacional Ciro Alegría