Influence of estrogens deficiency on body weight and glucose levels

de-la-Cruz-Rodríguez R.A.; Pacpac-Herrera L.S.; Franco-Quino C.; Mallma-Medina A.S.; Ruiz-Ramírez E.; Aguirre-Siancas E.E. · Revista Medica Electronica (2025)

Resumen

Introduction: Estrogens deficiency, characteristic of menopause or surgical removal of the ovaries could be related to weight gain and altered glycaemia, but the physiological mechanisms are unknown, generating a scientific gap. Objective: To assess the influence of estrogens deficiency on body weight and glucose levels. Methods: Twelve, female, BALB/c mice were equally and randomly divided into two groups: sham surgery and ovariectomy. Mice in the ovariectomy group had their ovaries removed bilaterally, while those in the sham surgery group had their ovaries exposed without removal. Twelve weeks later the mice were sacrificed following the protocol. The weights of the mice were monitored one day before surgery and then monthly for three consecutive months. Preprandial and postprandial glucose levels were also measured before surgery and at 12 weeks after surgery. Results: An increase in body weight was observed from the first month in favor of the ovariectomized group (p<0.05); also, preprandial and postprandial glucose levels were increased in the ovariectomized group. Conclusion: Estrogens deficiency leads to increased body weight and altered postprandial and preprandial glucose levels in female mice. © Los artículos de Revista Médica Electrónica de la Universidad de Ciencias Médicas de Matanzas se comparten bajo los términos de la Licencia Creative Commons Atribución– NoComercial 4.0.

Instituciones: Universidad Peruana Cayetano Heredia; Universidad Nacional Mayor de San Marcos