Increased Prevalence of Antibodies to Hepatitis E Virus in Patients with Neurocysticercosis

Abanto J.; Sanchez Boluarte A.N.; Castillo Y.; Perez E.; Saavedra H.; Gonzales I.; Bustos J.A.; Abravanel F.; Izopet J.; Madden R.G.; Garcia H.H.; Dalton H.R. · American Journal of Tropical Medicine and Hygiene (2024) · DOI: 10.4269/ajtmh.23-0856

Resumen

We explored the association between serological status for hepatitis E and neurocysticercosis (NCC) in neurologic patients attending a national neurological referral center in Lima, Perú, between the years 2008 and 2012. Anti-hepatitis E antibodies were evaluated in patients with and without NCC, and a control group of rural general population. Anti-hepatitis E IgG was found in 23.8% of patients with NCC, compared with 14.3% in subjects without NCC from a general rural population (P 5 0.023) and 14.4% in subjects with neurological complaints without NCC (P 5 0.027). Seropositive patients had a median age of 44 years compared with 30 years in seronegative patients (P,0.001). No significant differences in sex, region of residence, or liver enzyme values were found. Seropositivity to hepatitis E was frequent in this Peruvian population and higher in patients with NCC, suggesting shared common routes of infection.

Instituciones: Universidad Peruana Cayetano Heredia