In Vivo Study of the Safety and Skin Viscoelasticity of a Cosmetic Formulation Containing an Extract and Oils from Peruvian Native Plants

Lozada P.; Victoria-Tinoco L.; Rojas Valdivia J.G.; Muñoz A.M.; Ricaldi J.H. · Natural Product Communications (2025) · DOI: 10.1177/1934578x251404289

Resumen

Objectives: This study aimed to evaluate the safety of daily use and skin viscoelasticity in vivo and under long-term conditions (14 and 28 days) of a cosmetic cream containing an extract of dragon's blood (Croton lechleri Muell) and vegetable oils from aguaje (Mauritia flexuosa Lf.), goldenberry (Physalis peruviana L.), super sacha inchi (Plukenetia huayllabambana), and sacha inchi (Plukenetia volubilis), all of which are of Peruvian origin. Methods: Dermatological safety and viscoelasticity tests were conducted using the International Contact Dermatitis Research Group evaluation scale for measuring reactions and the Cutometer® MPA580, respectively. Results: The results reported that the cosmetic cream in the safety evaluation did not induce any significant skin sensitisation or irritant phenomena; and in the long-term viscoelastic evaluation significant increases were achieved with respect to the baseline control (p = 0.000): the indices of firmness, viscoelasticity during the suction phase and total recovery, obtained average improvements of 29.5%; 39.0%; 37.7%, respectively. Conclusion: The cosmetic cream is dermatologically safe and demonstrates a sustainable improvement effect on the viscoelasticity parameter and increases firmness gradually after 14 and 28 days of daily application. © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Instituciones: Universidad San Ignacio de Loyola