IL28B gene polymorphisms are not associated with the risk of HTLV-1 infection: A Meta-Analysis

Quiroz-Ruiz H.R.; Miranda-Ulloa E.; León-Torres C.A.; Bardales-Vásquez C.B. · Gaceta Medica Boliviana (2025) · DOI: 10.47993/gmb.v48i2.1027

Resumen

The investigation of genetic risk factors is important for understanding susceptibility to Human T-Cell Lymphotropic Virus Type 1 (HTLV-1). Although IL28B gene polymorphisms have been implicated in infection risk for other viruses, their role in HTLV-1 infection risk remains uncertain. Objective: to determine whether the Single Nucleotide Polymorphisms (SNPs) rs8099917 and rs12979860 in the IL28B gene are associated with the risk of HTLV-1 infection. Material and Methods: a meta-analysis of case-control studies was performed. A search was conducted in PubMed, Google Scholar, and Scopus. Genotypic frequencies of the polymorphisms were extracted. Using a genetic association meta-analysis with the Metagenyo software, Odds Ratios (OR) and 95% confidence intervals were estimated for four genetic models. Results: four studies were included, comprising 875 participants for rs12979860 and 718 for rs8099917. No deviation from Hardy-Weinberg equilibrium was observed (p>0.05). No statistically significant association was found between rs12979860 and HTLV-1 infection risk (allelic model: OR=0.98; p=0.89; recessive model: OR=1.03; p=0.85; dominant model: OR=0.91; p=0.63; overdominant model: OR=0.92; p=0.59), nor for rs8099917 (allelic model: OR=1.01; p=0.97; recessive model: OR=0.95; p=0.78; dominant model: OR=1.09; p=0.80; overdominant model: OR=1.12; p=0.53). Conclusion: This meta-analysis indicates that the SNPs rs8099917 and rs12979860 are not associated with the risk of HTLV-1 infection. This underscores the need for further case-control studies to validate our findings.

Instituciones: Universidad Nacional de Trujillo; Universidad Privada Antenor Orrego