Identification of the allele HLA B*57:01 in a military population, from Lima-Peru

Vilcarino-Zevallos G.; Espetia-Anco S.; Yaya-Rios M.; Cárdenas-Bustamante F.; Rodríguez-Bayona R.; Yabar-Varas C. · Revista Chilena de Infectologia (2024) · DOI: 10.4067/s0716-10182024000200311

Resumen

The HLA B*57:01 allele is a genetic marker associated with hypersensitivity to the antiretroviral Abacavir (ABC) and its frequency in the Peruvian population is still unknown. The objective was to identify the HLA B*57:01 allele in a military population from Lima, Peru. Forty three people living with HIV (PLWH) were recruited, who agreed to participate through informed consent. Detection of the HLA B*57:01 allele was performed by real-time PCR (RT-PCR). Likewise, viral load (VL), CD4 lymphocyte count and HIV genotyping were determined. Two cases positive for the HLA B*57:01 allele (4.7%) were identified. In addition, one of them had multiple resistance mutations to antiretrovirals (ARVs), including ABC. The presence of the HLA B*57:01 allele was demonstrated for the first time in Peru.

Instituciones: Universidad de San Martín de Porres