Hypocalcemia as a factor associated with mortality in ischemic cerebrovascular disease

Espinoza Baigorria A.F.; Cabanillas Mejía E.; Zavaleta-Corvera C.; De la Cruz Davila M.I.; Caballero-Alvarado J. · Neurologia Argentina (2025) · DOI: 10.1016/j.neuarg.2025.08.001

Resumen

Introduction There is evidence that calcium plays an important role in the pathogenesis of ischemic cerebrovascular accident (CVA), relating to the extent of ischemia and, therefore, to the patient's prognosis. This study aimed to determine if hypocalcemia is a predictor of in-hospital mortality in patients with ischemic cerebrovascular disease. Materials and methods Case-control study. I included medical records of 162 patients 1:1 (81 cases and 81 controls), seen between 2015 and 2018. The odds ratio (OR) was calculated and a multivariate logistic regression analysis was performed to evaluate hypocalcemia as a predictor of mortality in ischemic stroke. Results Ionic calcium was significantly lower in the deceased than in the controls (0.73 and 0.41 mmol/L, respectively, p < 0.001), with hypocalcemia being an independent predictor of mortality after multivariate analysis (ORa: 2.58; 95%CI).: 1.16-9.01). Likewise, the intervening factors evaluated were arterial hypertension (ORa: 5.13, 95%CI: 2.41-10.94), diabetes mellitus (ORa: 2.58, 95%CI: 1.18-5.62), previous stroke (ORa: 1.85, 95%CI).: 1.62-5.52) and presenting high c-reactive protein (ORa: 2.23, 95% CI: 1.92-5.42), the predictive factors that remained significant after performing the multivariate adjustment. Conclusion It is concluded that hypocalcemia is a predictor of in-hospital mortality due to ischemic stroke.

Instituciones: Universidad Privada Antenor Orrego